Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

A library of RNA bridges

Translation starts with the assembly of the ribosome from its subunits, which requires the formation of intersubunit bridges. A combinatorial mutagenesis approach has now identified a number of the 16S rRNA residues involved in intersubunit bridging that are functionally important for the ribosome.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Intersubunit bridges of the E. coli ribosome.

Accession codes


Protein Data Bank


  1. Frank, J. et al. Biochem. Cell Biol. 73, 757–765 (1995).

    Article  CAS  Google Scholar 

  2. Yusupov, M.M. et al. Science 292, 883–896 (2001).

    Article  CAS  Google Scholar 

  3. Gao, H. et al. Cell 113, 789–801 (2003).

    Article  CAS  Google Scholar 

  4. Schuwirth, B.S. et al. Science 310, 827–834 (2005).

    Article  CAS  Google Scholar 

  5. Gao, N. et al. Mol Cell. 18, 663–674 (2005).

    Article  CAS  Google Scholar 

  6. Rackham, O. & Chin, J.W. Nat. Chem. Biol. 2, 254–258 (2006).

    Article  CAS  Google Scholar 

  7. Frank, J. & Agrawal, R.K. Nature 406, 318–322 (2000).

    Article  CAS  Google Scholar 

  8. Valle, M. et al. Cell 114, 123–134 (2003).

    Article  CAS  Google Scholar 

  9. Carter, A.P. et al. Science 291, 498–501 (2001).

    Article  CAS  Google Scholar 

  10. Maivali, U. & Remme, J. RNA 10, 600–604 (2004).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and permissions

About this article

Cite this article

Gao, N., Frank, J. A library of RNA bridges. Nat Chem Biol 2, 231–232 (2006).

Download citation

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing