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Chemicals turn human embryonic stem cells towards beta cells

Nature Chemical Biology volume 5, pages 195–196 (2009)Cite this article

Small-molecule library screening identifies simple imitators of the cellular signaling events that normally guide formation of the pancreas and its insulin-secreting beta cells, further enabling detailed analysis in vitro, or eventual diabetes therapies via large-scale differentiation of human stem cells.

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Figure 1: Chemical-induced differentiation in vitro as a mimic of normal organogenesis.

Katie Vicari

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Authors and Affiliations

  1. Yu-Ping Yang and Chris Wright are in the Department of Cell and Developmental Biology and the Vanderbilt University Program in Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. chris.wright@vanderbilt.edu,

    Yu-Ping Yang & Chris Wright

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  1. Yu-Ping Yang
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  2. Chris Wright
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Yang, YP., Wright, C. Chemicals turn human embryonic stem cells towards beta cells. Nat Chem Biol 5, 195–196 (2009). https://doi.org/10.1038/nchembio0409-195

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