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Self-reporting peptides illuminate the MHC groove

Synthetic oligopeptides chemically modified with environmentally sensitive fluorophores enable real-time visualization of peptide binding to MHC molecules. This technology will expand our understanding of antigen presentation and enable visualization of fluorescent peptide binding to a wide variety of receptors in living cells.

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Figure 1: Location, location, location: self-reporting peptides identify peptide-receptive MHC molecules.

Katie Ris


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Yewdell, J., Lev, A. Self-reporting peptides illuminate the MHC groove. Nat Chem Biol 3, 201–202 (2007).

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