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Gold-plating MHC class II molecules

Square-planar, four-coordinate metal complexes strip peptides from the binding site of MHC class II molecules. Removal of peptides derived from self-antigens could prevent class II–dependent activation of self-reactive T cells in autoimmune diseases such as rheumatoid arthritis.

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Figure 1: Peptide binding is required for MHC class II-restricted T-cell activation.


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Roche, P. Gold-plating MHC class II molecules. Nat Chem Biol 2, 178–179 (2006).

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