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It's a mod mod tRNA world

Nature Chemical Biology volume 4, pages 162–164 (2008)Cite this article

Postsynthetic modifications are widespread in genetic regulation. Trm9-mediated modification of the anticodon wobble base of specific tRNAs modulates expression of DNA damage response mRNAs in which cognate codons are unusually overrepresented. Thus, modification-dependent tRNA decoding activity is keyed to codon use in a genetic program.

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Figure 1: U34 modifications increase specific activity of for decoding cognate codons during translation.

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Authors and Affiliations

  1. Richard J. Maraia, Nathan H. Blewett and Mark A. Bayfield are at the Intramural Research Program of the National Institute of Child Health and Human Development, National Institutes of Health, 31 Center Drive, Bethesda, Maryland 20892-2426, USA. maraiar@mail.nih.gov,

    Richard J Maraia, Nathan H Blewett & Mark A Bayfield

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  1. Richard J Maraia
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  2. Nathan H Blewett
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  3. Mark A Bayfield
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Maraia, R., Blewett, N. & Bayfield, M. It's a mod mod tRNA world. Nat Chem Biol 4, 162–164 (2008). https://doi.org/10.1038/nchembio0308-162

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