Taking the inventory inside single cells

Despite having an increasingly accurate parts list for biological cells, much is left to discover about how these parts act together to create functional cells, and how distinct individual cells interact to create functional tissues and organs. Biologists are increasingly aware of the cell-to-cell variability in molecule copy numbers—a trend that is revealed by several new techniques, including one that permits counting molecules in single cells.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Taking the inventory inside single cells.

Kim Caesar

References

  1. 1

    Elowitz, M.B., Levine, A.J., Siggia, E.D. & Swain, P.S. Science 297, 1183–1186 (2002).

    CAS  Article  Google Scholar 

  2. 2

    Chubb, J.R., Trcek, T., Shenoy, S.M. & Singer, R.H. Curr. Biol. 16, 1018–1025 (2006).

    CAS  Article  Google Scholar 

  3. 3

    Golding, I., Paulsson, J., Zawilski, S.M. & Cox, E.C. Cell 123, 1025–1036 (2005).

    CAS  Article  Google Scholar 

  4. 4

    Raj, A., Peskin, C.S., Tranchina, D., Vargas, D.Y. & Tyagi, S. PLoS Biol. 4, e309 (2006).

    Article  Google Scholar 

  5. 5

    Cai, L., Friedman, N. & Xie, X.S. Nature 440, 358–362 (2006).

    CAS  Article  Google Scholar 

  6. 6

    Huang, B. et al. Science 315, 81–84 (2007).

    CAS  Article  Google Scholar 

  7. 7

    Blake, W.J. Nature 422, 633–637 (2003).

    CAS  Article  Google Scholar 

  8. 8

    Ozbudak, E.M., Thattai, M., Kurtser, I., Grossman, A.D. & van Oudenaarden, A. Nat. Genet. 31, 69–73 (2002).

    CAS  Article  Google Scholar 

  9. 9

    Raser, J.M. & O'Shea, E.K. Science 304, 1811–1814 (2004).

    CAS  Article  Google Scholar 

  10. 10

    Thattai, M. & van Oudenaarden, A. Genetics 167, 523–530 (2004).

    Article  Google Scholar 

  11. 11

    Wolf, D.M., Vazirani, V.V. & Arkin, A.P. J. Theor. Biol. 234, 227–253 (2005).

    Article  Google Scholar 

  12. 12

    Blake, W.J. et al. Mol. Cell 24, 853–865 (2006).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Balázsi, G., Collins, J. Taking the inventory inside single cells. Nat Chem Biol 3, 141–142 (2007). https://doi.org/10.1038/nchembio0307-141

Download citation

Further reading

  • Parallel Networks

    • Tara L. Deans

    ACM Journal on Emerging Technologies in Computing Systems (2014)

Search

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing