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Flexible tetracycline synthesis yields promising antibiotics

Nature Chemical Biology volume 5, pages 7779 (2009) | Download Citation

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Access to new analogs of the tetracycline family of antibiotics has thus far been limited to compounds that can be prepared by modification of the isolable natural products. An efficient total-synthesis pathway with extraordinary flexibility has now made it possible to identify new tetracycline derivatives with activity against a wide range of antibiotic-resistant bacteria.

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Author information

Affiliations

  1. Martin D. Burke is in the Department of Chemistry, University of Illinois, Urbana, Illinois 61801, USA. burke@scs.uiuc.edu

    • Martin D Burke

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DOI

https://doi.org/10.1038/nchembio0209-77

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