Access to new analogs of the tetracycline family of antibiotics has thus far been limited to compounds that can be prepared by modification of the isolable natural products. An efficient total-synthesis pathway with extraordinary flexibility has now made it possible to identify new tetracycline derivatives with activity against a wide range of antibiotic-resistant bacteria.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Walsh, C.T. & Wright, G. Chem. Rev. 105, 391–392 (2005).
Stephens, C.R., Murai, K., Rennhard, H.H., Conover, L.H. & Brunings, K.J. J. Am. Chem. Soc. 80, 5324–5325 (1958).
Martell, M.J. & Boothe, J.H. J. Med. Chem. 10, 44–46 (1967).
Sun, C.S. et al. J. Am. Chem. Soc. 130, 17913–17927 (2008).
Conover, L.H., Butler, K., Johnston, J.D., Korst, J.J. & Woodward, R.B. J. Am. Chem. Soc. 84, 3222–3224 (1962).
Kolosov, M.N., Popravko, S.A. & Shemyakin, M.M. Liebigs Ann. 668, 86–91 (1963).
Muxfeldt, H., Hardtmann, G., Kathawala, F., Vedejs, E. & Mooberry, J.B. J. Am. Chem. Soc. 90, 6534–6536 (1968).
Charest, M.G., Lerner, C.D., Brubaker, J.D., Siegel, D.R. & Myers, A.G. Science 308, 395–398 (2005).
Stork, G. & Hagedorn, A.A. III . J. Am. Chem. Soc. 100, 3609–3611 (1978).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Burke, M. Flexible tetracycline synthesis yields promising antibiotics. Nat Chem Biol 5, 77–79 (2009). https://doi.org/10.1038/nchembio0209-77
Issue Date:
DOI: https://doi.org/10.1038/nchembio0209-77
