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Novel Wnt antagonists target porcupine and Axin

Nature Chemical Biology volume 5, pages 7475 (2009) | Download Citation

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Wnt signals are seemingly ubiquitous in biology, controlling processes as diverse as bristle patterning in flies and tissue regeneration in humans. A new report describes the discovery of small molecules that inhibit Wnt signaling by two unprecedented mechanisms, paving the way for fundamental studies and perhaps improved treatment of colon cancer.

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Affiliations

  1. Jing-Ruey J. Yeh and Randall T. Peterson are at the Cardiovascular Research Center, Massachusetts General Hospital, Harvard University, 149 13th Street, Charlestown, Massachusetts 02129, USA and the Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA. peterson@cvrc.mgh.harvard.edu

    • Jing-Ruey J Yeh
    •  & Randall T Peterson

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https://doi.org/10.1038/nchembio0209-74

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