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A ghost in the RNA machine

Nature Chemical Biology volume 5, pages 7374 (2009) | Download Citation

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The 'RNA World' hypothesis presupposes the existence of a catalytic RNA that can polymerize nucleotide triphosphates to replicate a template, but such chemistry has not previously been detected in natural ribozymes. Detailed investigation of the products of a bacterial self-splicing group I intron now suggest that such ribozymes indeed exist in nature.

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Author information

Affiliations

  1. Niles Lehman is in the Department of Chemistry, Portland State University, PO Box 751, Portland, Oregon 97207, USA. niles@pdx.edu

    • Niles Lehman

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DOI

https://doi.org/10.1038/nchembio0209-73

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