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'Sialidase sensitivity' of rotaviruses revisited

Nature Chemical Biology volume 5, pages 7172 (2009) | Download Citation

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Rotaviruses have been designated as 'sialidase sensitive' or 'sialidase insensitive', based on how their entry into cells is affected by treating cells with sialidases. A new study uses multiple methods, including saturation transfer difference NMR spectroscopy, to elucidate interesting interactions involving terminal and internal sialic acid moieties, concluding that 'sialidase insensitive' does not mean 'sialic acid independent'.

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References

  1. 1.

    , , , & Emerg. Infect. Dis. 9, 565–572 (2003).

  2. 2.

    & in Essentials of Glycobiology (eds. Varki, A. et al.) 199–218 (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, USA, 2009).

  3. 3.

    , & Glycoconj. J. 23, 27–37 (2006).

  4. 4.

    et al. J. Virol. 76, 4087–4095 (2002).

  5. 5.

    et al. Nat. Chem. Biol. 5, 91–93 (2009).

  6. 6.

    et al. J. Virol. 75, 2276–2287 (2001).

  7. 7.

    , , & J. Mol. Biol 367, 1215–1226. (2007).

  8. 8.

    & J. Biol. Chem. 258, 299–304 (1983).

  9. 9.

    et al. J. Infect. Dis. 192 (Suppl. 1), S30–S35 (2005).

  10. 10.

    et al. Nature 456, 648–652 (2008).

Download references

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Affiliations

  1. Kalyan Banda and Gagandeep Kang are in the Department of Gastrointestinal Sciences, Christian Medical College, Vellore, 632004, India. gkang@cmcvellore.ac.in

    • Kalyan Banda
    •  & Gagandeep Kang
  2. Ajit Varki is in the Departments of Medicine and Cellular & Molecular Medicine, University of California, San Diego, La Jolla, California 92093, USA. a1varki@ucsd.edu

    • Ajit Varki

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DOI

https://doi.org/10.1038/nchembio0209-71

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