Rotaviruses have been designated as 'sialidase sensitive' or 'sialidase insensitive', based on how their entry into cells is affected by treating cells with sialidases. A new study uses multiple methods, including saturation transfer difference NMR spectroscopy, to elucidate interesting interactions involving terminal and internal sialic acid moieties, concluding that 'sialidase insensitive' does not mean 'sialic acid independent'.
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Banda, K., Kang, G. & Varki, A. 'Sialidase sensitivity' of rotaviruses revisited. Nat Chem Biol 5, 71–72 (2009). https://doi.org/10.1038/nchembio0209-71
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DOI: https://doi.org/10.1038/nchembio0209-71
