Monomeric fluorescent proteins that change their emission characteristics as they mature have been successfully used to study the spatial and temporal dynamics of lysosome-associated membrane protein type 2A. This methodology provides a new means of studying cellular events in a dynamic mode.
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Dikici, E., Daunert, S. Fluorescent timers shine a light on protein trafficking. Nat Chem Biol 5, 70–71 (2009). https://doi.org/10.1038/nchembio0209-70
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DOI: https://doi.org/10.1038/nchembio0209-70