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Visualizing biochemical activities in living cells

Nature Chemical Biology volume 5, pages 6365 (2009) | Download Citation

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Autofluorescent proteins have become indispensable in our quest to visualize molecular events in living cells. Further progress in the visualization and quantification of all biochemical activities of the cell will require the introduction of additional and complementary methods for sensing and probing biomolecules. Here I highlight some of the areas where the development of new probes and labeling methods is eagerly awaited and where chemical biologists could make important contributions.

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Author information

Affiliations

  1. Kai Johnsson is at the Institute of Chemical Sciences and Engineering, École Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland. kai.johnsson@epfl.ch

    • Kai Johnsson

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Competing interests

K.J. is a cofounder of Covalys Biosciences, which exploits SNAP-tag for applications in protein labeling.

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DOI

https://doi.org/10.1038/nchembio0209-63

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