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The microtubule-pore gatekeeper

Cyclostreptin, a natural product, cell toxin and covalent modifier of microtubules, has been shown to bind irreversibly to a previously unidentified site on the outer wall of microtubules. The exterior low-affinity location seems to be a way-station for microtubule-stabilizing agents traveling to the high-affinity site in the microtubule interior.

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Figure 1: Microtubule structure and its interaction with paclitaxel and cyclostreptin


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This effort was supported by US National Institutes of Health grant CA-69571.

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Snyder, J. The microtubule-pore gatekeeper. Nat Chem Biol 3, 81–82 (2007).

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