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The microtubule-pore gatekeeper

Cyclostreptin, a natural product, cell toxin and covalent modifier of microtubules, has been shown to bind irreversibly to a previously unidentified site on the outer wall of microtubules. The exterior low-affinity location seems to be a way-station for microtubule-stabilizing agents traveling to the high-affinity site in the microtubule interior.

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Figure 1: Microtubule structure and its interaction with paclitaxel and cyclostreptin

References

  1. Orr, G.A., Verdier-Pinard, P., McDaid, H. & Horwitz, S.B. Oncogene 22, 7280–7295 (2003).

    Article  CAS  Google Scholar 

  2. Wani, M.C., Taylor, H.L., Wall, M.E., Coggan, P. & McPhail, A.T. J. Amer. Chem. Soc. 93, 2325–2327 (1971).

    Article  CAS  Google Scholar 

  3. Schiff, P.B., Fant, J. & Horwitz, S.B. Nature 277, 665–667 (1979).

    Article  CAS  Google Scholar 

  4. Buey, R.M. et al. Nat. Chem. Biol. 3, 117–125 (2007).

    Article  CAS  Google Scholar 

  5. Sato, B. et al. J. Antibiot. (Tokyo) 53, 204–206 (2000).

    Article  CAS  Google Scholar 

  6. Edler, M.C. et al. Biochemistry 44, 11525–11538 (2005).

    Article  Google Scholar 

  7. Silverman, R.B. The Organic Chemistry of Drug Design and Drug Action (Elsevier, New York, 2004).

    Google Scholar 

  8. Diaz, J.F., Barasoain, I., Souto, A.A., Amat-Guerri, F. & Andreu, J.M. J. Biol. Chem. 280, 3928–3937 (2005).

    Article  CAS  Google Scholar 

  9. Ross, J.L. & Fygenson, D.K. Biophys. J. 84, 3959–3967 (2003).

    Article  CAS  Google Scholar 

  10. Baille, T.A. Chem. Res. Toxicol. 19, 889–893 (2006).

    Article  Google Scholar 

Download references

Acknowledgements

This effort was supported by US National Institutes of Health grant CA-69571.

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Snyder, J. The microtubule-pore gatekeeper. Nat Chem Biol 3, 81–82 (2007). https://doi.org/10.1038/nchembio0207-81

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