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Sweet insights into learning and memory

Nature Chemical Biologyvolume 2pages6768 (2006) | Download Citation

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Studies have linked the Fucα(1-2)Gal modification of neuronal glycoproteins to cognitive processes such as learning and memory. The identification of synapsins Ia and Ib as the main Fucα(1-2)Gal-bearing neuronal proteins not only suggests previously unknown molecular mechanisms of neuronal plasticity but also indicates the existence of previously unknown glycosylation pathways in neurons.

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References

  1. 1

    Spitzer, N.C. Nat. Neurosci. 2, 489–491 (1999).

  2. 2

    Bullock, S., Potter, J. & Rose, S.P. J. Neurochem. 54, 135–142 (1990).

  3. 3

    Matthies, H., Sabine, S. & Krug, M. Brain Res. 725, 276–280 (1996).

  4. 4

    Murrey, H.E. et al. Proc. Natl. Acad. Sci. USA 103, 21–26 (2006).

  5. 5

    Camilli, P.D., Benfenati, F. & Greengard, P. Ann. Rev. Cell Biol. 6, 433–460 (1990).

  6. 6

    West, C.M. Cell Mol. Life Sci. 60, 229–240 (2003).

  7. 7

    Hart, G.W., Haltiwanger, R.S., Holt, G.D. & Kelly, W.G. Annu. Rev. Biochem. 58, 841–874 (1989).

  8. 8

    Wells, L., Vosseller, K. & Hart, G.W. Science 291, 2376–2378 (2001).

  9. 9

    Cole, R.N. & Hart, G.W. J. Neurochem. 79, 1080–1089 (2001).

  10. 10

    Cole, R.N. & Hart, G.W. J. Neurochem. 73, 418–428 (1999).

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  1. Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, 21205-2185, Maryland, USA

    • Gerald W Hart

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https://doi.org/10.1038/nchembio0206-67

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