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Decoding endocannabinoid signaling

Development of an inhibitor of an endocannabinoid-degrading enzyme provides insights into the role of 2-arachidonoylglycerol in the nervous system.

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Figure 1: 2-AG biosynthesis, degradation and signaling through the CB1 receptor.

References

  1. Di Marzo, V., De Petrocellis, L. & Bisogno, T. Handb. Exp. Pharmacol. 168, 147–185 (2005).

    Article  CAS  Google Scholar 

  2. Cravatt, B.F. et al. Proc. Natl. Acad. Sci. USA 98, 9371–9376 (2001).

    Article  CAS  Google Scholar 

  3. Lichtman, A.H. et al. J. Pharmacol. Exp. Ther. 311, 441–448 (2004).

    Article  CAS  Google Scholar 

  4. Long, J.Z. et al. Nat. Chem. Biol. 5, 37–44 (2009).

    Article  CAS  Google Scholar 

  5. Kathuria, S. et al. Nat. Med. 9, 76–81 (2003).

    Article  CAS  Google Scholar 

  6. Mackie, K. Annu. Rev. Pharmacol. Toxicol. 46, 101–122 (2006).

    Article  CAS  Google Scholar 

  7. Edgemond, W.S., Hillard, C.J., Falck, J.R., Kearn, C.S. & Campbell, W.B. Mol. Pharmacol. 54, 180–188 (1998).

    Article  CAS  Google Scholar 

  8. Woodward, D.F. et al. Pharmacol. Ther. 120, 71–80 (2008).

    Article  CAS  Google Scholar 

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Marnett, L. Decoding endocannabinoid signaling. Nat Chem Biol 5, 8–9 (2009). https://doi.org/10.1038/nchembio0109-8

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