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Engineering fluorination

Nature Chemical Biology volume 5, pages 67 (2009) | Download Citation


Cytochrome P450 enzymes selectively oxidize relatively unactivated sites in a range of model drug-like substrates in vitro. The hydroxylated products can be transformed into selectively fluorinated systems, providing a rapid sequential method for the identification, activation and fluorination of saturated sites in drug candidates.

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  1. Grahamm Sandford is Professor of Chemistry at the Department of Chemistry, Durham University, South Road, Durham DH1 3LE, UK.

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