Cytochrome P450 enzymes selectively oxidize relatively unactivated sites in a range of model drug-like substrates in vitro. The hydroxylated products can be transformed into selectively fluorinated systems, providing a rapid sequential method for the identification, activation and fluorination of saturated sites in drug candidates.
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Sandford, G. Engineering fluorination. Nat Chem Biol 5, 6–7 (2009). https://doi.org/10.1038/nchembio0109-6
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DOI: https://doi.org/10.1038/nchembio0109-6