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Metabolomics cuts to the chase to chase the cuts

Peptidases are enzymes that trim small protein fragments called peptides to regulate their biological functions. A new method opens the door to chasing down and identifying important cutting events mediated by peptidases involved in metabolic regulation.

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Figure 1: Metabolomic identification of downstream substrates of DPP4.

Kim Caesar

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Bogyo, M. Metabolomics cuts to the chase to chase the cuts. Nat Chem Biol 5, 5–6 (2009). https://doi.org/10.1038/nchembio0109-5

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