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IP7 guards the CDK gate

Analyses of mutants affecting the synthesis of inositol phosphates have uncovered a variety of new roles for these small molecules in cells, but identification of their physiological targets has lagged behind. New studies on the yeast phosphate starvation response have brought the inositol pyrophosphate IP7 and its mechanism of action into sharp focus.

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Figure 1: The mechanism of action of IP7.

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York, J., Lew, D. IP7 guards the CDK gate. Nat Chem Biol 4, 16–17 (2008). https://doi.org/10.1038/nchembio0108-16

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