News & Views | Published:

Chemical expansion of cofactor activity

Nature Chemical Biology volume 2, pages 810 (2006) | Download Citation

Subjects

Methylation is a key regulatory event in several biological processes. The enzymatic transfer by methyltransferases of extended carbon chain analogs of S-adenosylmethionine to DNA opens up new avenues for investigating biological methylation.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    et al. Nat. Chem. Biol. 2, 31–32 (2006).

  2. 2.

    et al. FEBS Lett. 556, 26–34 (2004).

  3. 3.

    et al. J. Am. Chem. Soc. 127, 11234–11235 (2005).

  4. 4.

    , & Trends Biochem. Sci. 28, 329–335 (2003).

  5. 5.

    et al. FASEB J. 10, 471–480 (1996).

  6. 6.

    , & Birth Defects Res. C. Embryo Today 75, 98–111 (2005).

  7. 7.

    & J. Natl. Cancer Inst. 86, 753–759 (1994).

  8. 8.

    , & Angew. Chem. Int. Edn Engl. 40, 2004–2021 (2001).

  9. 9.

    , , & Nat. Methods 2, 99–104 (2005).

  10. 10.

    & J. Am. Chem. Soc. 116, 12083–12084 (1994).

  11. 11.

    et al. Biochemistry 30, 5674–5681 (1991).

Download references

Author information

Affiliations

  1. Andrew C. Mercer and Michael D. Burkart are in the Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0358, USA. mburkart@ucsd.edu

    • Andrew C Mercer
    •  & Michael D Burkart

Authors

  1. Search for Andrew C Mercer in:

  2. Search for Michael D Burkart in:

About this article

Publication history

Published

DOI

https://doi.org/10.1038/nchembio0106-8

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing