Neurotransmitter binding to a member of the Cys-loop receptor superfamily elicits opening of an ion channel by inducing a change in the configuration of a prolyl imide bond. Engineering a series of mutant receptors to contain proline analogues with a range of cis/trans preferences demonstrates the molecular basis for channel gating.
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Andreotti, A. Opening the pore hinges on proline. Nat Chem Biol 2, 13–14 (2006). https://doi.org/10.1038/nchembio0106-13
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DOI: https://doi.org/10.1038/nchembio0106-13