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Opening the pore hinges on proline

Nature Chemical Biology volume 2, pages 1314 (2006) | Download Citation

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Neurotransmitter binding to a member of the Cys-loop receptor superfamily elicits opening of an ion channel by inducing a change in the configuration of a prolyl imide bond. Engineering a series of mutant receptors to contain proline analogues with a range of cis/trans preferences demonstrates the molecular basis for channel gating.

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Author information

Affiliations

  1. Amy H. Andreotti is in the Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, 4208 Molecular Biology Building, Ames, Iowa 50011, USA. amyand@iastate.edu

    • Amy H Andreotti

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DOI

https://doi.org/10.1038/nchembio0106-13

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