Hedgehog signaling has important and pleiotropic roles in embryonic and adult tissues. A small-molecule agonist of this pathway has been shown to act by targeting the transmembrane protein Smoothened.
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Jessica Iannuzzi
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Briscoe, J. Agonizing Hedgehog. Nat Chem Biol 2, 10–11 (2006). https://doi.org/10.1038/nchembio0106-10
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DOI: https://doi.org/10.1038/nchembio0106-10
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