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Immunology

Csk keeps LYP on a leash

Lymphoid tyrosine phosphatase (LYP) is often mutated in humans suffering from autoimmune diseases. A recent study proposes a mechanism by which LYP can cause these diseases and suggests that drugs against LYP could be a useful treatment.

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Figure 1: Impact of the R620W mutation on LYP activity and autoimmune diseases.

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Correspondence to André Veillette.

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The authors declare no competing financial interests.

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Zhong, MC., Veillette, A. Csk keeps LYP on a leash. Nat Chem Biol 8, 412–413 (2012). https://doi.org/10.1038/nchembio.940

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