The activity of the anaphase-promoting complex is regulated by the autoubiquitination of Cdc20. How this autoubiquitination is regulated remains an open question. The pharmacological inhibitor TAME now provides insight into this regulation.
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Foe, I., Toczyski, D. Taming the APC. Nat Chem Biol 8, 323–324 (2012). https://doi.org/10.1038/nchembio.923
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DOI: https://doi.org/10.1038/nchembio.923
