Histone deacetylation

IP4 is an epigenetic coregulator

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Inositol tetraphosphate is required for both the incorporation of the histone deacetylase HDAC3 into a repressive complex and its enzymatic activity.

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Figure 1: The role of IP4 in the assembly and function of the SMRT–HDAC3 repression complex.

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Correspondence to Tatiana G Kutateladze.

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The author declares no competing financial interests.

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Kutateladze, T. IP4 is an epigenetic coregulator. Nat Chem Biol 8, 230–231 (2012) doi:10.1038/nchembio.795

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