The glycosyltransferase-catalyzed generation of sugar nucleotides is normally an unfavorable endothermic process. Simple reactive glycosides used in conjunction with mutant transferases enable such reactions to become favorable exothermic processes, providing practical access to a diverse range of non-natural sugar nucleotides.
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References
Varki, A. et al. (eds.). Essentials of Glycobiology, 2nd edn. (Cold Spring Harbor Laboratory Press, 2009).
Kiessling, L.L. & Splain, R.A. Annu. Rev. Biochem. 79, 619–653 (2010).
Schmaltz, R.M. et al. Chem. Rev. 111, 4259–4307 (2011).
Palcic, M.M. Curr. Opin. Chem. Biol. 15, 226–266 (2011).
Gantt, R.W. et al. Nat. Chem. Biol. 7, 685–691 (2011).
Kadokawa, J. Chem. Rev. 111, 4308–4345 (2011).
Wagner, G.K. et al. Nat. Prod. Rep. 26, 1172–1194 (2009).
Thibodeaux, C.J. et al. Angew. Chem. Int. Ed. Engl. 47, 9814–9859 (2008).
Lougheed, B. et al. J. Biol. Chem. 274, 37717–37722 (1999).
Lairson, L.L. et al. Chem. Commun. (Camb.) 365–367 (2007).
Zhang, C. et al. Science 313, 1291–1294 (2006).
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Field, R. Challenging reaction equilibria. Nat Chem Biol 7, 658–659 (2011). https://doi.org/10.1038/nchembio.668
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DOI: https://doi.org/10.1038/nchembio.668
