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GPCRs

Caught in a spectroscopic trap

Nature Chemical Biology volume 7, pages 578579 (2011) | Download Citation

Homo- and heterodimerization of G protein–coupled receptors (GPCRs) have been described for numerous receptors, but their functional role has remained elusive. With a new spectroscopic assay based on protein fragment complementation, GPCR heterodimerization was demonstrated to contribute to a phenomenon called 'functional selectivity'.

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Author information

Affiliations

  1. Jacob Piehler is in the Biology Department at the University of Osnabrück in Osnabrück, Germany.

    • Jacob Piehler

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Competing interests

The author declares no competing financial interests.

Corresponding author

Correspondence to Jacob Piehler.

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DOI

https://doi.org/10.1038/nchembio.641

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