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Amyloidogenesis

FlAsH illuminates Aβ aggregation

Nature Chemical Biology volume 7, pages 581582 (2011) | Download Citation

Protein misfolding, oligomerization and aggregation are implicated in a variety of neurodegenerative disorders, including Alzheimer's and Parkinson's diseases. New research sheds light on the process of amyloid-β aggregation in vitro, identifying nucleated conformational conversion of oligomers as the mechanism for generating amyloid fibrils.

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Author information

Affiliations

  1. Tiago F. Outeiro is in the Cell and Molecular Neuroscience Unit at the Instituto de Medicina Molecular and the Instituto de Fisiologia in the Faculdade de Medicina da Universidade de Lisboa in Lisboa, Portugal, and the Department of Neurodegeneration and Restorative Research, Center for Molecular Physiology of the Brain, Universitätsmedizin Göttingen, Göttingen, Germany.

    • Tiago F Outeiro

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Competing interests

The author declares no competing financial interests.

Corresponding author

Correspondence to Tiago F Outeiro.

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DOI

https://doi.org/10.1038/nchembio.636

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