The combination of NMR spectroscopy and statistical mechanics represents a powerful approach to characterize the behavior of macromolecules. Two recent studies demonstrate that the application of this strategy to analyze chemical shift measurements can reveal complex mechanisms of protein regulation.
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A Tool Set to Map Allosteric Networks through the NMR Chemical Shift Covariance Analysis
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Vendruscolo, M. The statistical theory of allostery. Nat Chem Biol 7, 411–412 (2011). https://doi.org/10.1038/nchembio.603
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DOI: https://doi.org/10.1038/nchembio.603
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A Tool Set to Map Allosteric Networks through the NMR Chemical Shift Covariance Analysis
Scientific Reports (2014)