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RNA folding

A tale of two riboswitches

Nature Chemical Biology volume 7, pages 342–343 (2011)Cite this article

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Riboswitches are so named because they switch gene expression on or off in response to binding of specific metabolites. Two evolutionarily and mechanistically divergent riboswitches that recognize the universal methyl donor S-adenosylmethionine are shown to undergo dynamic conformational sampling before ligand binding.

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Figure 1: Conformational switching behavior of SAM-I and SAM-II riboswitches.

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Authors and Affiliations

  1. Ming C. Hammond is in the Departments of Chemistry and of Molecular & Cell Biology at the University of California–Berkeley, Berkeley, California, USA,

    Ming C Hammond

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  1. Ming C Hammond
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Correspondence to Ming C Hammond.

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The author declares no competing financial interests.

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Hammond, M. A tale of two riboswitches. Nat Chem Biol 7, 342–343 (2011). https://doi.org/10.1038/nchembio.588

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