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Signal transduction

STIM1 senses both Ca2+ and heat

Nature Chemical Biology volume 7, pages 344–345 (2011)Cite this article

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STIM proteins are ubiquitous endoplasmic reticulum Ca2+ sensors that rapidly translocate to couple with 'store-operated' Orai Ca2+ channels when luminal Ca2+ levels are low. STIM1 also senses heat changes, which trigger a similar translocation and prime STIM1 to activate Orai, suggesting that STIM1 functions as a sensor of multiple stress signals.

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Figure 1: STIM1 activation results from either Ca2+ sensing or temperature sensing.

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Authors and Affiliations

  1. Youjun Wang and Donald L. Gill are in the Department of Biochemistry, Salvatore Mancarella, Temple University School of Medicine, Philadelphia, Pennsylvania, USA.,

    Salvatore Mancarella, Youjun Wang & Donald L Gill

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  1. Salvatore Mancarella
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  2. Youjun Wang
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  3. Donald L Gill
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Correspondence to Donald L Gill.

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Competing interests

D.L.G. is partly supported by Novartis Institutes for Biomedical Research.

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Mancarella, S., Wang, Y. & Gill, D. STIM1 senses both Ca2+ and heat. Nat Chem Biol 7, 344–345 (2011). https://doi.org/10.1038/nchembio.587

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