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Protein aggregation

p53 succumbs to peer pressure

A small subpeptide from the tumor suppressor p53 is shown to mediate aggregation that is similar to that of amyloids. The result is nucleated assembly by mutant p53 that can abrogate function of wild-type p53 and its two functionally important homologs.

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Figure 1: The energetics of dominant negative aggregation.

References

  1. Oren, M. & Rotter, V. Cold Spring Harb. Perspect. Biol. 2, a001107 (2010).

    Article  Google Scholar 

  2. Joerger, A.C. & Fersht, A.R. Cold Spring Harb. Perspect. Biol. 2, a000919 (2010).

    Article  Google Scholar 

  3. Xu, J. et al. Nat. Chem. Biol. 7, 285–295 (2011).

    Article  CAS  Google Scholar 

  4. Fernandez-Escamilla, A.M., Rousseau, F., Schymkowitz, J. & Serrano, L. Nat. Biotechnol. 22, 1302–1306 (2004).

    Article  CAS  Google Scholar 

  5. Li, Y. & Prives, C. Oncogene 26, 2220–2225 (2007).

    Article  CAS  Google Scholar 

  6. Goldschmidt, L., Teng, P.K., Riek, R. & Eisenberg, D. Proc. Natl. Acad. Sci. USA 107, 3487–3492 (2010).

    Article  CAS  Google Scholar 

  7. Ruschak, A.M. & Miranker, A.D. Proc. Natl. Acad. Sci. USA 104, 12341–12346 (2007).

    Article  CAS  Google Scholar 

  8. Hebda, J.A. & Miranker, A.D. Annu. Rev. Biophys. 38, 125–152 (2009).

    Article  CAS  Google Scholar 

  9. Hebda, J.A., Saraogi, I., Magzoub, M., Hamilton, A.D. & Miranker, A.D. Chem. Biol. 16, 943–950 (2009).

    Article  CAS  Google Scholar 

  10. Sawaya, M.R. et al. Nature 447, 453–457 (2007).

    Article  CAS  Google Scholar 

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Correspondence to Andrew D Miranker.

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Magzoub, M., Miranker, A. p53 succumbs to peer pressure. Nat Chem Biol 7, 248–249 (2011). https://doi.org/10.1038/nchembio.569

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  • DOI: https://doi.org/10.1038/nchembio.569

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