Parathyroid hormone analog PTH(1–34), used clinically to treat osteoporosis, forms a stable complex with its receptor and prolongs cAMP production even after internalization and recruitment to endosomes. New data suggest this signaling cascade is stimulated by β-arrestins and terminated by retromer.
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Katie Vicari
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van Weering, J., Cullen, P. Retromer arrests receptor on the run. Nat Chem Biol 7, 251–252 (2011). https://doi.org/10.1038/nchembio.564
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DOI: https://doi.org/10.1038/nchembio.564
