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Carbohydrate dynamics

Antibody glycans wiggle and jiggle

Many proteins bear sugar residues that modulate their functionality. Clues about the energy landscape and accessibility of sugar conformations in immunoglobulin G will contribute to an understanding of the mechanistic and energetic aspects of glycobiology and immunology.

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Figure 1: Structure of IgG carrying an N-linked glycan at Asn297.

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Correspondence to Jens Duus.

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Meier, S., Duus, J. Antibody glycans wiggle and jiggle. Nat Chem Biol 7, 131–132 (2011). https://doi.org/10.1038/nchembio.526

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