Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Post-translational modifications

S-linked sugars lost and found

The vast majority of core structures of protein and peptide glycosylation motifs belong to either O-linked or N-linked glycans. A recent publication describes the structure and biosynthesis of an unusual S-linked glycan linkage in the antibacterial glycopeptide sublancin.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Glycan structures old and new.

References

  1. Lote, C.J. & Weiss, J.B. FEBS Lett. 16, 81 (1971).

    Article  CAS  Google Scholar 

  2. Pachamuthu, K. & Schmidt, R.R. Chem. Rev. 106, 160 (2006).

    Article  CAS  Google Scholar 

  3. Macauley, M.S., Stubbs, K.A. & Vocadlo, D.J. J. Am. Chem. Soc. 127, 17202 (2005).

    Article  CAS  Google Scholar 

  4. Rich, J.R., Szpacenko, A., Palcic, M.M. & Bundle, D.R. Angew. Chem. Int. Ed. 43, 613 (2004).

    Article  CAS  Google Scholar 

  5. Namdjou, D. et al. ChemBioChem 9, 1632 (2008).

    Article  CAS  Google Scholar 

  6. Oman, T.J. et al. Nat. Chem. Biol. 7, 78–80 (2011).

    Article  CAS  Google Scholar 

  7. Oman, T.J. & van der Donk, W.A. Nat. Chem. Biol. 6, 9–18 (2010).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Sabine L Flitsch.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Šardzík, R., Both, P. & Flitsch, S. S-linked sugars lost and found. Nat Chem Biol 7, 69–70 (2011). https://doi.org/10.1038/nchembio.516

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nchembio.516

This article is cited by

Search

Quick links

Nature Briefing Microbiology

Sign up for the Nature Briefing: Microbiology newsletter — what matters in microbiology research, free to your inbox weekly.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing: Microbiology