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Chromatin

A ubiquitin crowbar opens chromatin

Nature Chemical Biology volume 7, pages 6869 (2011) | Download Citation

Monoubiquitylation of histone H2B is found to disrupt condensation of chemically defined chromatin fibers. A novel fluorescence-based assay is used in concert with analytical ultracentrifugation to uncover the synergistic roles of histone acetylation and ubiquitylation on chromatin dynamics.

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Author information

Affiliations

  1. Craig L. Peterson is in the Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.

    • Craig L Peterson

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Competing interests

The author declares no competing financial interests.

Corresponding author

Correspondence to Craig L Peterson.

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DOI

https://doi.org/10.1038/nchembio.514

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