The nonreceptor tyrosine kinase Btk has emerged as a new molecular target for the treatment of B cell lymphoma and autoimmune disorders. A newly discovered specific small-molecule Btk inhibitor that uniquely stabilizes Btk in an inactive conformation suppresses inflammation in rheumatoid arthritis.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Inflammasome activation controlled by the interplay between post-translational modifications: emerging drug target opportunities
Cell Communication and Signaling Open Access 24 February 2021
-
Highly selective inhibition of Bruton’s tyrosine kinase attenuates skin and brain disease in murine lupus
Arthritis Research & Therapy Open Access 25 January 2018
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Di Paolo, J.A. et al. Nat. Chem. Biol. 7, 41–50 (2010).
Leandro, M.J. & de la Torre, I. Clin. Exp. Immunol. 157, 191–197 (2009).
Sanz, I. & Lee, F.E.-H. Nat. Rev. Rheumatol. 6, 326–337 (2010).
Jumaa, H., Hendriks, R.W. & Reth, M. Annu. Rev. Immunol. 23, 415–445 (2005).
Petro, J.B., Rahman, S.M., Ballard, D.W. & Khan, W.N. J. Exp. Med. 191, 1745–1754 (2000).
Bajpai, U.D., Zhang, K., Teutsch, M., Sen, R. & Wortis, H.H. J. Exp. Med. 191, 1735–1744 (2000).
Davis, R.E. et al. Nature 463, 88–92 (2010).
Weinblatt, M.E. et al. N. Engl. J. Med. 363, 1303–1312 (2010).
Honigberg, L.A. et al. Proc. Natl. Acad. Sci. USA 107, 13075–13080 (2010).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Hendriks, R. New Btk inhibitor holds promise. Nat Chem Biol 7, 4–5 (2011). https://doi.org/10.1038/nchembio.502
Published:
Issue Date:
DOI: https://doi.org/10.1038/nchembio.502
This article is cited by
-
Inflammasome activation controlled by the interplay between post-translational modifications: emerging drug target opportunities
Cell Communication and Signaling (2021)
-
Novel Therapies for Pemphigus Vulgaris
American Journal of Clinical Dermatology (2020)
-
Neuropsychiatric lupus: new mechanistic insights and future treatment directions
Nature Reviews Rheumatology (2019)
-
Highly selective inhibition of Bruton’s tyrosine kinase attenuates skin and brain disease in murine lupus
Arthritis Research & Therapy (2018)
-
The pre-B-cell receptor checkpoint in acute lymphoblastic leukaemia
Leukemia (2015)
