Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

A decade of chemical biology

Nature Chemical Biology volume 6, pages 847–854 (2010)Cite this article

Subjects

With insights from a panel of experts, the Nature Chemical Biology editors examine the evolution and current era of chemical biology.

Twenty years ago, chemical biology was just an idea. Since then, that idea has evolved into a global community of scientists dedicated to understanding science at the intersections of chemistry and biology. How did this major transformation occur, and where is chemical biology going next?

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Learn more

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Key chemical biology discoveries over the past decade.

Katie Vicari

References

  1. Borman, S. Chem. Eng. News 85, 31–32 (2007).

    Article  Google Scholar 

  2. Elbashir, S.M. et al. Nature 411, 494–498 (2001).

    Article  CAS  PubMed  Google Scholar 

  3. Ban, N. et al. Science 289, 905–920 (2000).

    Article  CAS  PubMed  Google Scholar 

  4. Wimberly, B.T. et al. Nature 407, 327–339 (2000).

    Article  CAS  PubMed  Google Scholar 

  5. Bentley, S.D. et al. Nature 417, 141–147 (2002).

    Article  PubMed  Google Scholar 

  6. Washburn, M.P. et al. Nat. Biotechnol. 19, 242–247 (2001).

    Article  CAS  PubMed  Google Scholar 

  7. Liu, Y., Patricelli, M.P. & Cravatt, B.F. Proc. Natl. Acad. Sci. USA 96, 14694–14699 (1999).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Saxon, E. & Bertozzi, C.R. Science 287, 2007–2010 (2000).

    Article  CAS  PubMed  Google Scholar 

  9. Lewis, W.G. et al. Angew. Chem. Int. Ed. 41, 1053–1057 (2002).

    Article  CAS  Google Scholar 

  10. Noren, C.J., Anthony-Cahill, S.J., Griffith, M.C. & Schultz, P.G. Science 244, 182–188 (1989).

    Article  CAS  PubMed  Google Scholar 

  11. Wang, L. et al. Science 292, 498–500 (2001).

    Article  CAS  PubMed  Google Scholar 

  12. Dawson, P.E., Muir, T.W., Clark-Lewis, I. & Kent, S.B. Science 266, 776–779 (1994).

    Article  CAS  PubMed  Google Scholar 

  13. McGinty, R.K. et al. Nature 453, 812–816 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Bishop, A.C. et al. Nature 407, 395–401 (2000).

    Article  CAS  PubMed  Google Scholar 

  15. Druker, B.J. et al. N. Engl. J. Med. 344, 1031–1037 (2001).

    Article  CAS  PubMed  Google Scholar 

  16. Knight, Z.A. et al. Cell 125, 733–747 (2006).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Rasmussen, S.G. et al. Nature 450, 383–387 (2007).

    Article  CAS  PubMed  Google Scholar 

  18. Cherezov, V. et al. Science 318, 1258–1265 (2007).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Lamb, J. et al. Science 313, 1929–1935 (2006).

    Article  CAS  PubMed  Google Scholar 

  20. Anonymous, Nat. Chem. Biol. 6, 385 (2010).

  21. Plante, O.J., Palmacci, E.R. & Seeberger, P.H. Science 291, 1523–1527 (2001).

    Article  CAS  PubMed  Google Scholar 

  22. McKemy, D.D., Neuhausser, W.M. & Julius, D. Nature 416, 52–58 (2002).

    Article  CAS  PubMed  Google Scholar 

  23. Hopkins, A.L. & Groom, C.R. Nat. Rev. Drug Discov. 1, 727–730 (2002).

    Article  CAS  PubMed  Google Scholar 

  24. Kuhlman, B. et al. Science 302, 1364–1368 (2003).

    Article  CAS  PubMed  Google Scholar 

  25. Rak, A. et al. Science 302, 646–650 (2003).

    Article  CAS  PubMed  Google Scholar 

  26. Chiti, F. et al. Nature 424, 805–808 (2003).

    Article  CAS  PubMed  Google Scholar 

  27. Lynch T.J. et al. N. Engl. J. Med. 350, 2129–2139 (2004).

    Article  CAS  PubMed  Google Scholar 

  28. Shi, Y. et al. Cell 119, 941–953 (2004).

    Article  CAS  PubMed  Google Scholar 

  29. Parsons, A.B. et al. Nat. Biotechnol. 22, 62–69 (2004).

    Article  CAS  PubMed  Google Scholar 

  30. Berns, K. et al. Nature 428, 431–437 (2004).

    Article  CAS  PubMed  Google Scholar 

  31. Fabian, M.A. et al. Nat. Biotechnol. 23, 329–336 (2005).

    Article  CAS  PubMed  Google Scholar 

  32. Dharmasiri, N., Dharmasiri, S. & Estelle, M. Nature 441, 431–445 (2005).

    Google Scholar 

  33. Singh, V. et al. J. Biol. Chem. 280, 18265–18273 (2005).

    Article  CAS  PubMed  Google Scholar 

  34. Boyden, E.S. et al. Nat. Neurosci. 8, 1263–1268 (2005).

    Article  CAS  PubMed  Google Scholar 

  35. Rust, M.J., Bates, M. & Zhuang, X. Nat. Methods 3, 793–795 (2006).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. Wang, J. et al. Nature 441, 358–361 (2006).

    Article  CAS  PubMed  Google Scholar 

  37. Nören-Müller, A. et al. Proc. Natl. Acad. Sci. USA 103, 10606–10611 (2006).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  38. Livet, J. et al. Nature 450, 56–62 (2007).

    Article  CAS  PubMed  Google Scholar 

  39. Hermann, J.C. et al. Nature 448, 775–779 (2007).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Song, L. et al. Nat. Chem. Biol. 3, 486–491 (2007).

    Article  CAS  PubMed  Google Scholar 

  41. Baran, P.S., Maimone, T.J. & Richter, J.M. Nature 446, 404–408 (2007).

    Article  CAS  PubMed  Google Scholar 

  42. Shi, Y. et al. Cell Stem Cell 3, 568–574 (2008).

    Article  CAS  PubMed  Google Scholar 

  43. Balch, W.E. et al. Science 319, 916–919 (2008).

    Article  CAS  PubMed  Google Scholar 

  44. Young, D.W. et al. Nat. Chem. Biol. 4, 59–68 (2008).

    Article  CAS  PubMed  Google Scholar 

  45. Tokuriki, N. & Tawfik, D.S. Nature 459, 668–673 (2009).

    Article  CAS  PubMed  Google Scholar 

  46. Bok, J.W. et al. Nat. Chem. Biol. 5, 462–464 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. Wolan, D.W. et al. Science 326, 853–858 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  48. Runguphan, W. & O'Connor, S.E. Nat. Chem. Biol. 5, 151–153 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. Sinha, J., Reyes, S.J. & Gallivan, J.P. Nat. Chem. Biol. 6, 464–470 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  50. Zhang, Y. et al. Nature 465, 891–896 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  51. Gamo, F. -J. et al. Nature 465, 305–310 (2010).

    Article  CAS  PubMed  Google Scholar 

  52. Guiguemde, W.A. et al. Nature 465, 311–315 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  53. Uttamapinant, C. et al. Proc. Natl. Acad. Sci. USA 107, 10914–10919 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Authors
  1. Mirella Bucci
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Catherine Goodman
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Terry L Sheppard
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Bucci, M., Goodman, C. & Sheppard, T. A decade of chemical biology. Nat Chem Biol 6, 847–854 (2010). https://doi.org/10.1038/nchembio.489

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nchembio.489

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing