Some of the most celebrated triumphs of chemical biology are molecularly targeted therapeutics to combat human disease. However, a grand challenge looms as informative diagnostic strategies must be developed to realize the full impact of these promising pharmaceutical agents.
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Lander, E.S. et al. Nature 409, 860–921 (2001).
Venter, J.C. et al. Science 291, 1304–1351 (2001).
Druker, B.J. et al. N. Engl. J. Med. 344, 1031–1037 (2001).
Lynch, T.J. et al. N. Engl. J. Med. 350, 2129–2139 (2004).
Paez, J.G. et al. Science 304, 1497–1500 (2004).
Garber, K. Science 326, 1619 (2009).
Oltersdorf, T. et al. Nature 435, 677–681 (2005).
Ferraris, D.V. J. Med. Chem. 53, 4561–4584 (2010).
Vassilev, L.T. et al. Science 303, 844–848 (2004).
Wiman, K.G. Oncogene 29, 4245–4252 (2010).
Peterson, Q.P. et al. Cancer Res. 70, 7232–7241 (2010).
Hudis, C.A. N. Engl. J. Med. 357, 39–51 (2007).
Sawyers, C.L. Nature 452, 548–552 (2008).
Schröder, F.H. et al. N. Engl. J. Med. 360, 1320–1328 (2009).
Street, J.M. & Dear, J.W. Br. J. Clin. Pharmacol. 69, 367–378 (2010).
Kodadek, T., Reddy, M.M., Olivos, H.J., Bachhawat-Sikder, K. & Alluri, P.G. Acc. Chem. Res. 37, 711–718 (2004).
Cho, E.J., Lee, J.W. & Ellington, A.D. Ann. Rev. Anal. Chem. 2, 241–264 (2009).
Agnew, H.D. et al. Angew. Chem. Int. Ed. Engl. 48, 4944–4948 (2009).
Weissleder, R. & Pittet, M.J. Nature 452, 580–589 (2008).
The author declares no competing financial interests.
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Bailey, R. Grand Challenge Commentary: Informative diagnostics for personalized medicine. Nat Chem Biol 6, 857–859 (2010). https://doi.org/10.1038/nchembio.488
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