A new method to monitor interactions between cell surface proteins reveals that interaction of the neuronal cell surface adhesion proteins neurexin and neuroligin is increased at synapses during a stimulus or developmental activity. This increased activity-dependent surface density of neurexin–neuroligin complexes is subsequently required for maturation of synapses.
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Miyawaki, A. Visualizing a neuronal handshake. Nat Chem Biol 6, 885–886 (2010). https://doi.org/10.1038/nchembio.486
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DOI: https://doi.org/10.1038/nchembio.486
