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Grand Challenge Commentary: Chassis cells for industrial biochemical production

Hyper-performing whole-cell catalysts are required for the renewable and sustainable production of petrochemical replacements. Chassis cells—self-replicating minimal machines that can be tailored for the production of specific chemicals—will provide the starting point for designing these hyper-performing 'turbo cells'.

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Figure 1: Designing hyper-producing whole-cell catalysts.

References

  1. Luisi, P.L., Oberholzer, T. & Lazcano, A. Helv. Chim. Acta 85, 1759–1777 (2002).

    Article  CAS  Google Scholar 

  2. Gil, R., Silva, F.J., Pereto, J. & Moya, A. Microbiol. Mol. Biol. Rev. 68, 518–537 (2004).

    Article  CAS  Google Scholar 

  3. Morimoto, T. et al. DNA Res. 15, 73–81 (2008).

    Article  CAS  Google Scholar 

  4. Gibson, D.G. et al. Science 329, 52–56 (2010).

    Article  CAS  Google Scholar 

  5. Lee, S.Y. & Park, J.H. Adv. Biochem. Eng. Biotechnol. 120, 1–19 (2010).

    CAS  PubMed  Google Scholar 

  6. Lu, T.K., Khalil, A.S. & Collins, J.J. Nat. Biotechnol. 27, 1139–1150 (2009).

    Article  CAS  Google Scholar 

  7. Canton, B., Labno, A. & Endy, D. Nat. Biotechnol. 26, 787–793 (2008).

    Article  CAS  Google Scholar 

  8. Schmid, A., Kortmann, H., Dittrich, P.S. & Blank, L.M. Curr. Opin. Biotechnol. 21, 12–20 (2010).

    Article  CAS  Google Scholar 

  9. Alper, H., Moxley, J., Nevoigt, E., Fink, G.R. & Stephanopoulos, G. Science 314, 1565–1568 (2006).

    Article  CAS  Google Scholar 

  10. Neumann, H., Wang, K.H., Davis, L., Garcia-Alai, M. & Chin, J.W. Nature 464, 441–444 (2010).

    Article  CAS  Google Scholar 

  11. Koopman, F., Wierckx, N., de Winde, J.H. & Ruijssenaars, H.J. Proc. Natl. Acad. Sci. USA 107, 4919–4924 (2010).

    Article  CAS  Google Scholar 

  12. Blank, L.M., Ionidis, G., Ebert, B.E., Bühler, B. & Schmid, A. FEBS J. 275, 5173–5190 (2008).

    Article  CAS  Google Scholar 

  13. Dueber, J.E. et al. Nat. Biotechnol. 27, 753–759 (2009).

    Article  CAS  Google Scholar 

  14. Buntin, K., Weissman, K.J. & Muller, R. ChemBioChem 11, 1137–1146 (2010).

    Article  CAS  Google Scholar 

  15. Feist, A.M. & Palsson, B.O. Nat. Biotechnol. 26, 659–667 (2008).

    Article  CAS  Google Scholar 

  16. Luo, B., Groenke, K., Takors, R., Wandrey, C. & Oldiges, M. J. Chromatogr. A 1147, 153–164 (2007).

    Article  CAS  Google Scholar 

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Correspondence to Claudia E Vickers.

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Vickers, C., Blank, L. & Krömer, J. Grand Challenge Commentary: Chassis cells for industrial biochemical production. Nat Chem Biol 6, 875–877 (2010). https://doi.org/10.1038/nchembio.484

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