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Grand Challenge Commentary: Accessing new chemical space for 'undruggable' targets

The synthesis and biological annotation of small molecules from underexplored chemical space will play a central role in the development of drugs for challenging targets currently being identified in frontier areas of biological research such as human genetics.

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Figure 1
Figure 2: Analysis of structural complexity of MLSMR collection.

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Correspondence to Sivaraman Dandapani or Lisa A Marcaurelle.

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Dandapani, S., Marcaurelle, L. Grand Challenge Commentary: Accessing new chemical space for 'undruggable' targets. Nat Chem Biol 6, 861–863 (2010). https://doi.org/10.1038/nchembio.479

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