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Grand Challenge Commentary: Chemical transdifferentiation and regenerative medicine

The ability to alter cell identity with small molecules represents a powerful approach to restore biological function lost because of cellular deficiency. Developing this capability through advances in chemical biology could have an enormous impact on human health.

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Figure 1: Examples illustrating the goal of altering cell fate using small molecules.
Figure 2: Transdifferentiation may help restore beta-cell mass lost in type 1 diabetes.


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Correspondence to Bridget K Wagner.

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The author declares no competing financial interests.

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Wagner, B. Grand Challenge Commentary: Chemical transdifferentiation and regenerative medicine. Nat Chem Biol 6, 877–879 (2010).

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