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Grand Challenge Commentary: Beyond discovery: probes that see, grab and poke

Nature Chemical Biology volume 6, pages 868–870 (2010)Cite this article

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Chemical biology is now able to discover molecules that manipulate virtually any biological target or process. It remains a grand challenge to leverage these molecules into useful probes that can be used to address unsolved problems in biology.

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Figure 1: The probe development challenge.
Figure 2: A few general methods for probe development.

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  1. Joshua A. Kritzer is in the Department of Chemistry, Tufts University, Medford, Massachusetts, USA.,

    Joshua A Kritzer

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  1. Joshua A Kritzer
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Correspondence to Joshua A Kritzer.

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The author declares no competing financial interests.

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Kritzer, J. Grand Challenge Commentary: Beyond discovery: probes that see, grab and poke. Nat Chem Biol 6, 868–870 (2010). https://doi.org/10.1038/nchembio.469

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