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A story of thrift unfolds

Although members of the Hsp70-DnaK family of heat shock proteins are involved in nearly all aspects of cell physiology, some mechanistic details of their mode of action remain obscure. A new substrate helps establish DnaK as an unfoldase that requires as little as five ATP molecules to drive the refolding of one protein.

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Figure 1: DnaK structure and unfoldase function.


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Correspondence to Brent L Nannenga.

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Baneyx, F., Nannenga, B. A story of thrift unfolds. Nat Chem Biol 6, 880–881 (2010).

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