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Protein engineering

Check nature first, then evolve

Ten significantly active new (R)-transaminases, still very rare enzymes, were found among 21 designed variants obtained from nothing more than existing transaminase structures and alignment of pertinent fingerprints of annotated sequences.

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Figure 1: Evaluation of active site environment and of fingerprints in multiple sequence alignments of transaminases.

Katherine Vicari


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Correspondence to Andreas S Bommarius.

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Bommarius, A. Check nature first, then evolve. Nat Chem Biol 6, 793–794 (2010).

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