Many nuclear and cytoplasmic proteins are post-translationally modified by both O-GlcNAc and phosphate, but determining whether a single copy of a protein bears multiple modifications remains a challenge. A new analytic approach reveals a surprising correlation between phosphorylation and the O-GlcNAc modification.
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References
Torres, C.R. & Hart, G.W. J. Biol. Chem. 259, 3308–3317 (1984).
Hart, G.W., Housley, M.P. & Slawson, C. Nature 446, 1017–1022 (2007).
Shafi, R. et al. Proc. Natl. Acad. Sci. USA 97, 5735–5739 (2000).
McClain, D.A. et al. Proc. Natl. Acad. Sci. USA 99, 10695–10699 (2002).
Hanover, J.A. et al. Proc. Natl. Acad. Sci. USA 102, 11266–11271 (2005).
Fujiki, R. et al. Nature 459, 455–459 (2009).
Rexach, J. E. et al. Nat. Chem. Biol. 6, 645–651 (2010).
Hart, G.W. et al. Adv. Exp. Med. Biol. 376, 115–123 (1995).
Wells, L., Kreppel, L.K., Comer, F.I., Wadzinski, B.E. & Hart, G.W. J. Biol. Chem. 279, 38466–38470 (2004).
Mikesh, L.M. et al. Biochim. Biophys. Acta 1764, 1811–1822 (2006).
Tao, J. et al. Proc. Natl. Acad. Sci. USA 106, 4882–4887 (2009).
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Kohler, J. A shift for the O-GlcNAc paradigm. Nat Chem Biol 6, 634–635 (2010). https://doi.org/10.1038/nchembio.429
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DOI: https://doi.org/10.1038/nchembio.429
