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Post-translational modifications

A shift for the O-GlcNAc paradigm

Many nuclear and cytoplasmic proteins are post-translationally modified by both O-GlcNAc and phosphate, but determining whether a single copy of a protein bears multiple modifications remains a challenge. A new analytic approach reveals a surprising correlation between phosphorylation and the O-GlcNAc modification.

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Figure 1: Mapping multiple post-translational modifications.


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Correspondence to Jennifer J Kohler.

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Kohler, J. A shift for the O-GlcNAc paradigm. Nat Chem Biol 6, 634–635 (2010).

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